Assay Detail
Binding
CHEMBL672170
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Binding affinity towards human Dopamine receptor D2 using [3H]spiroperidol as radioligand
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.22 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.92 |
| CHEMBL152262 | — | — | 1 | 7.20 |
| CHEMBL433741 | — | — | 1 | 7.11 |
| CHEMBL152010 | — | — | 1 | 6.97 |
| CHEMBL346692 | — | — | 1 | 6.87 |
| CHEMBL2112910 | — | — | 1 | 6.77 |
| CHEMBL423040 | — | — | 1 | 6.68 |
| CHEMBL152869 | — | — | 1 | 6.60 |
| CHEMBL196476 | — | — | 1 | 6.43 |
| CHEMBL152304 | — | — | 1 | 6.37 |
| CHEMBL286725 | — | — | 1 | 6.33 |
| CHEMBL152159 | — | — | 1 | 6.17 |
| CHEMBL152587 | — | — | 1 | 6.11 |
| CHEMBL345820 | — | — | 1 | 6.08 |
| CHEMBL152756 | — | — | 1 | 6.03 |
| CHEMBL152576 | — | — | 1 | 5.95 |
| CHEMBL152391 | — | — | 1 | 5.85 |
| CHEMBL347290 | — | — | 1 | 5.81 |
| CHEMBL93403 | — | — | 1 | 5.72 |
| CHEMBL315879 | — | — | 1 | 5.63 |
| CHEMBL357448 | — | — | 1 | 5.52 |
| CHEMBL156599 | — | — | 1 | 5.43 |
| CHEMBL61789 | — | — | 1 | 5.42 |
| CHEMBL92713 | — | — | 1 | 5.40 |
| CHEMBL154508 | — | — | 1 | 5.28 |
| CHEMBL2112911 | — | — | 1 | 5.24 |
| CHEMBL156845 | — | — | 1 | 5.13 |
| CHEMBL152679 | — | — | 1 | - |
| CHEMBL157222 | — | — | 1 | - |
| CHEMBL157322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL152262 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL433741 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL152010 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL346692 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL2112910 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL423040 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL152869 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL196476 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL152304 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL286725 | — | Ki | = | 467.0 | nM | 6.33 |
| CHEMBL152159 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL152587 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL345820 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL152756 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL152576 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL152391 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL347290 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL93403 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL315879 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL357448 | — | Ki | = | 2990.0 | nM | 5.52 |
| CHEMBL156599 | — | Ki | = | 3680.0 | nM | 5.43 |
| CHEMBL61789 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL92713 | — | Ki | = | 3960.0 | nM | 5.40 |
| CHEMBL154508 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL2112911 | — | Ki | = | 5740.0 | nM | 5.24 |
| CHEMBL156845 | — | Ki | = | 7460.0 | nM | 5.13 |
| CHEMBL2112905 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL345111 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL345848 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL154050 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL305362 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL94265 | — | Ki | > | 850.0 | nM | - |
| CHEMBL157388 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL157322 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL157222 | — | Ki | > | 8300.0 | nM | - |
| CHEMBL152679 | — | Ki | > | 1000.0 | nM | - |