Assay Detail
Binding
CHEMBL672183
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Displacement of [3H]quinpirole from Dopamine receptor D2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.16 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.80 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.72 |
| CHEMBL138998 | — | — | 1 | 8.31 |
| CHEMBL69985 | — | — | 1 | 7.58 |
| CHEMBL139089 | — | — | 1 | 7.43 |
| CHEMBL141510 | — | — | 1 | 7.34 |
| CHEMBL139345 | — | — | 1 | 6.78 |
| CHEMBL65847 | — | — | 1 | 6.75 |
| CHEMBL141511 | — | — | 1 | 6.59 |
| CHEMBL138792 | — | — | 1 | 6.23 |
| CHEMBL141537 | — | — | 1 | 6.11 |
| CHEMBL345087 | — | — | 1 | 5.82 |
| CHEMBL342630 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL59 | DOPAMINE | Ki | = | 1.89 | nM | 8.72 |
| CHEMBL138998 | — | Ki | = | 4.94 | nM | 8.31 |
| CHEMBL69985 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL139089 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL141510 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL139345 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL65847 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL141511 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL138792 | — | Ki | = | 585.0 | nM | 6.23 |
| CHEMBL141537 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL345087 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL342630 | — | Ki | = | 2450.0 | nM | 5.61 |