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Compound Detail

CHEMBL69985

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CCCN(CCC)[C@@H]1CCc2c(F)cccc2C1

Basic Information

ChEMBL ID CHEMBL69985
Phase Preclinical
Structure Type MOL
InChI Key WFENTJXFRAVXHY-CQSZACIVSA-N
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

249.4
MW (Da)
3.81
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H24FN
MW 249.37
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness -1.03

Activity Summary

Ki 7 meas. best 8.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL234
Ki 8.06 8.06 8.6 1
D(2) dopamine receptor
CHEMBL217
Ki 7.58 7.14 26.0 4
5-hydroxytryptamine receptor 1A
CHEMBL273
Ki 7.52 7.195 30.2 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10465538 10.1016/s0960-894x(99)00345-5 D(2) dopamine receptor 6
8893836 10.1021/jm960350p D(2) dopamine receptor 5
8893836 10.1021/jm960350p D(3) dopamine receptor 4
8893836 10.1021/jm960350p 5-hydroxytryptamine receptor 1A 1
8831769 10.1021/jm960329o 5-hydroxytryptamine receptor 1A 1

Data from ChEMBL 36 via Core Engine