Assay Detail
Binding
CHEMBL616069
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Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.78 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87195 | — | — | 1 | 9.15 |
| CHEMBL555098 | — | — | 1 | 9.05 |
| CHEMBL538787 | — | — | 1 | 8.96 |
| CHEMBL26998 | — | — | 1 | 8.89 |
| CHEMBL41436 | — | — | 1 | 8.74 |
| CHEMBL87348 | — | — | 1 | 8.74 |
| CHEMBL131449 | — | — | 1 | 8.74 |
| CHEMBL131547 | — | — | 1 | 8.42 |
| CHEMBL544838 | — | — | 1 | 8.31 |
| CHEMBL441088 | — | — | 1 | 8.26 |
| CHEMBL41716 | — | — | 1 | 8.21 |
| CHEMBL338581 | — | — | 1 | 8.16 |
| CHEMBL545069 | — | — | 1 | 8.16 |
| CHEMBL545533 | — | — | 1 | 8.12 |
| CHEMBL130922 | — | — | 1 | 8.08 |
| CHEMBL337049 | — | — | 1 | 8.03 |
| CHEMBL131501 | — | — | 1 | 8.02 |
| CHEMBL542475 | — | — | 1 | 7.87 |
| CHEMBL130524 | — | — | 1 | 7.87 |
| CHEMBL540064 | — | — | 1 | 7.86 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.82 |
| CHEMBL88157 | — | — | 1 | 7.77 |
| CHEMBL541333 | — | — | 1 | 7.74 |
| CHEMBL131776 | — | — | 1 | 7.73 |
| CHEMBL543660 | — | — | 1 | 7.73 |
| CHEMBL22778 | — | — | 1 | 7.61 |
| CHEMBL545298 | — | — | 1 | 7.52 |
| CHEMBL130206 | — | — | 1 | 7.52 |
| CHEMBL128187 | — | — | 1 | 7.49 |
| CHEMBL542952 | — | — | 1 | 7.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87195 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL555098 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL538787 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL26998 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL41436 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL87348 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL131449 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL131547 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL544838 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL441088 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL41716 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL545069 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL338581 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL545533 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL130922 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL337049 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL131501 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL542475 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL130524 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL540064 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL49 | BUSPIRONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL88157 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL541333 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL543660 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL131776 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL22778 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL545298 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL130206 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL128187 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL542952 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL542727 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL335095 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL88504 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL541859 | — | Ki | = | 88.9 | nM | 7.05 |
| CHEMBL130552 | — | Ki | = | 88.9 | nM | 7.05 |
| CHEMBL69985 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL541858 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL552643 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL130550 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL544362 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL339845 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL554241 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL542474 | — | Ki | < | 0.3 | nM | - |
| CHEMBL555356 | — | Ki | < | 0.3 | nM | - |
| CHEMBL558994 | — | Ki | < | 0.3 | nM | - |