Assay Detail
Binding
CHEMBL616096
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Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.14 | 9.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138998 | — | — | 1 | 9.61 |
| CHEMBL139089 | — | — | 1 | 8.19 |
| CHEMBL65847 | — | — | 1 | 7.54 |
| CHEMBL69985 | — | — | 1 | 7.52 |
| CHEMBL141510 | — | — | 1 | 7.35 |
| CHEMBL139345 | — | — | 1 | 6.97 |
| CHEMBL141511 | — | — | 1 | 6.36 |
| CHEMBL141537 | — | — | 1 | 6.31 |
| CHEMBL138792 | — | — | 1 | 6.28 |
| CHEMBL342630 | — | — | 1 | 6.20 |
| CHEMBL345087 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138998 | — | Ki | = | 0.246 | nM | 9.61 |
| CHEMBL139089 | — | Ki | = | 6.46 | nM | 8.19 |
| CHEMBL65847 | — | Ki | = | 28.8 | nM | 7.54 |
| CHEMBL69985 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL141510 | — | Ki | = | 44.5 | nM | 7.35 |
| CHEMBL139345 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL141511 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL141537 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL138792 | — | Ki | = | 525.0 | nM | 6.28 |
| CHEMBL342630 | — | Ki | = | 627.0 | nM | 6.20 |
| CHEMBL345087 | — | Ki | = | 644.0 | nM | 6.19 |