Assay Detail
Binding
CHEMBL672206
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Binding affinity determined by measuring its ability to displace [3H]N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aminopyrimidines with high affinity for both serotonin and dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.56 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164792 | — | — | 1 | 8.52 |
| CHEMBL349426 | — | — | 1 | 8.49 |
| CHEMBL78791 | — | — | 1 | 8.47 |
| CHEMBL164604 | — | — | 1 | 8.33 |
| CHEMBL165047 | — | — | 1 | 8.32 |
| CHEMBL165679 | — | — | 1 | 8.28 |
| CHEMBL165664 | — | — | 1 | 8.24 |
| CHEMBL351617 | — | — | 1 | 8.22 |
| CHEMBL165056 | — | — | 1 | 8.22 |
| CHEMBL165140 | — | — | 1 | 8.13 |
| CHEMBL349034 | — | — | 1 | 8.07 |
| CHEMBL350352 | — | — | 1 | 7.96 |
| CHEMBL355371 | — | — | 1 | 7.92 |
| CHEMBL164723 | — | — | 1 | 7.60 |
| CHEMBL3084971 | — | — | 1 | 7.55 |
| CHEMBL309623 | — | — | 1 | 7.42 |
| CHEMBL164979 | — | — | 1 | 7.41 |
| CHEMBL166252 | — | — | 1 | 7.34 |
| CHEMBL165440 | — | — | 1 | 6.96 |
| CHEMBL2110308 | — | — | 2 | 6.80 |
| CHEMBL165689 | — | — | 1 | 6.75 |
| CHEMBL349980 | — | — | 1 | 6.62 |
| CHEMBL165381 | — | — | 1 | 5.62 |
| CHEMBL166151 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164792 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL349426 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL78791 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL164604 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL165047 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL165679 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL165664 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL351617 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL165056 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL165140 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL349034 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL350352 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL355371 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL164723 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3084971 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL309623 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL164979 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL166252 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL165440 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2110308 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL165689 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL349980 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2110308 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL165381 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL166151 | — | Ki | = | 4800.0 | nM | 5.32 |