Compound Detail
CHEMBL78791
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Basic Information
| ChEMBL ID | CHEMBL78791 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CEJURZXMIYUTSE-MXVIHJGJSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
397.6
MW (Da)
4.25
ALogP
4
HBA
1
HBD
35.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 9.1 | 9.1 | 0.8 | 2 |
| D(2) dopamine receptor CHEMBL217 | Ki | 8.47 | 8.47 | 3.4 | 2 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 7.24 | 7.24 | 57.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 0.8 | nM | 9.1 | Ability to displace radioligand [3H]spiperone from human dopamine D3 receptor tr... | - |
| D(3) dopamine receptor | Ki | = | 0.8 | nM | 9.1 | Binding affinity determined by measuring displacement of [3H]spiperone from clon... | 9513604 |
| D(2) dopamine receptor | Ki | = | 3.4 | nM | 8.47 | Ability to displace radioligand [3H]N-0437 from human dopamine D2 receptor trans... | - |
| D(2) dopamine receptor | Ki | = | 3.4 | nM | 8.47 | Binding affinity determined by measuring its ability to displace [3H]N-0437 radi... | 9513604 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 57.0 | nM | 7.24 | The binding affinity by measuring its ability to displace [3H]8-OH-DPAT radiolig... | 9513604 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00443-5 | D(2) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00443-5 | D(3) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00443-5 | Dopamine receptors; D2 & D3 | 1 |
| 9513604 | 10.1021/jm9707378 | D(2) dopamine receptor | 1 |
| 9513604 | 10.1021/jm9707378 | D(3) dopamine receptor | 1 |
| 9513604 | 10.1021/jm9707378 | 5-hydroxytryptamine receptor 1A | 1 |
Data from ChEMBL 36 via Core Engine