Assay Detail
Binding
CHEMBL674835
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Binding affinity determined by measuring displacement of [3H]spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aminopyrimidines with high affinity for both serotonin and dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.58 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349426 | — | — | 1 | 10.70 |
| CHEMBL309623 | — | — | 1 | 9.85 |
| CHEMBL78791 | — | — | 1 | 9.10 |
| CHEMBL164604 | — | — | 1 | 8.43 |
| CHEMBL164723 | — | — | 1 | 8.33 |
| CHEMBL350352 | — | — | 1 | 8.30 |
| CHEMBL164792 | — | — | 1 | 7.96 |
| CHEMBL165679 | — | — | 1 | 7.86 |
| CHEMBL165047 | — | — | 1 | 7.62 |
| CHEMBL355371 | — | — | 1 | 7.58 |
| CHEMBL3084971 | — | — | 1 | 7.54 |
| CHEMBL351617 | — | — | 1 | 7.50 |
| CHEMBL165056 | — | — | 1 | 7.50 |
| CHEMBL165440 | — | — | 1 | 7.40 |
| CHEMBL349034 | — | — | 1 | 7.32 |
| CHEMBL165140 | — | — | 1 | 7.27 |
| CHEMBL165664 | — | — | 1 | 7.05 |
| CHEMBL165689 | — | — | 1 | 6.68 |
| CHEMBL2110308 | — | — | 2 | 6.26 |
| CHEMBL349980 | — | — | 1 | 6.23 |
| CHEMBL165381 | — | — | 1 | 6.10 |
| CHEMBL166151 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349426 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL309623 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL78791 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL164604 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL164723 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL350352 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL164792 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL165679 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL165047 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL355371 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3084971 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL351617 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL165056 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL165440 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL349034 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL165140 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL165664 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL165689 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2110308 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL349980 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL2110308 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL165381 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL166151 | — | Ki | = | 2300.0 | nM | 5.64 |