Assay Detail
Binding
CHEMBL672383
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Displacement of [3H]spiperone from human Dopamine receptor D2L expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.52 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.39 |
| CHEMBL140258 | — | — | 1 | 6.30 |
| CHEMBL344270 | — | — | 1 | 6.10 |
| CHEMBL143355 | — | — | 1 | 5.85 |
| CHEMBL344602 | — | — | 1 | 5.70 |
| CHEMBL141035 | — | — | 1 | 5.64 |
| CHEMBL140165 | — | — | 1 | 5.62 |
| CHEMBL140099 | — | — | 1 | 5.51 |
| CHEMBL342001 | — | — | 1 | 5.37 |
| CHEMBL343880 | — | — | 1 | 5.25 |
| CHEMBL140594 | — | — | 1 | 5.10 |
| CHEMBL143761 | — | — | 1 | 4.55 |
| CHEMBL142217 | — | — | 1 | 4.47 |
| CHEMBL140006 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL140258 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL344270 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL143355 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL344602 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL141035 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL140165 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL140099 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL342001 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL343880 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL140594 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL143761 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL142217 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL140006 | — | Ki | = | 43000.0 | nM | 4.37 |