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Compound Detail

CHEMBL142217

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N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1

Basic Information

ChEMBL ID CHEMBL142217
Phase Preclinical
Structure Type MOL
InChI Key VHPASGHENHNLAW-UHFFFAOYSA-N
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

316.4
MW (Da)
3.36
ALogP
3
HBA
1
HBD
46.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20N4
MW 316.41
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -1.59

Activity Summary

Ki 5 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 7.3 7.3 50.0 1
D(1A) dopamine receptor
CHEMBL2967
Ki 5.52 5.52 3000.0 1
D(2) dopamine receptor
CHEMBL217
Ki 5.46 4.965 3500.0 2
D(3) dopamine receptor
CHEMBL234
Ki 5.36 5.36 4400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11087581 10.1021/jm0009989 D(2) dopamine receptor 2
11087581 10.1021/jm0009989 D(1A) dopamine receptor 1
11087581 10.1021/jm0009989 D(3) dopamine receptor 1
11087581 10.1021/jm0009989 D(4) dopamine receptor 1

Data from ChEMBL 36 via Core Engine