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Assay Detail

CHEMBL675671

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]spiperone from human Dopamine receptor D3 expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Hübner H, Kraxner J, Gmeiner P.
J Med Chem (2000) 43 : 4563 -4569
PubMed 11087581 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.39 6.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143355 1 6.26
CHEMBL344270 1 6.06
CHEMBL140258 1 6.04
CHEMBL141035 1 5.77
CHEMBL140099 1 5.77
CHEMBL343880 1 5.51
CHEMBL142217 1 5.36
CHEMBL140165 1 5.28
CHEMBL342001 1 5.19
CHEMBL140594 1 4.89
CHEMBL143761 1 4.82
CHEMBL140006 1 4.70
CHEMBL344602 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143355 Ki = 550.0 nM 6.26
CHEMBL344270 Ki = 870.0 nM 6.06
CHEMBL140258 Ki = 920.0 nM 6.04
CHEMBL141035 Ki = 1700.0 nM 5.77
CHEMBL140099 Ki = 1700.0 nM 5.77
CHEMBL343880 Ki = 3100.0 nM 5.51
CHEMBL142217 Ki = 4400.0 nM 5.36
CHEMBL140165 Ki = 5200.0 nM 5.28
CHEMBL342001 Ki = 6400.0 nM 5.19
CHEMBL140594 Ki = 13000.0 nM 4.89
CHEMBL143761 Ki = 15000.0 nM 4.82
CHEMBL140006 Ki = 20000.0 nM 4.70
CHEMBL344602 Ki = 33000.0 nM 4.48