Assay Detail
Binding
CHEMBL675088
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Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.89 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.38 |
| CHEMBL344270 | — | — | 1 | 6.35 |
| CHEMBL140165 | — | — | 1 | 6.31 |
| CHEMBL143355 | — | — | 1 | 6.29 |
| CHEMBL342001 | — | — | 1 | 6.26 |
| CHEMBL142217 | — | — | 1 | 5.52 |
| CHEMBL141035 | — | — | 1 | 5.12 |
| CHEMBL140099 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL344270 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL140165 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL143355 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL342001 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL142217 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL141035 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL140099 | — | Ki | = | 13000.0 | nM | 4.89 |