Assay Detail
Binding
CHEMBL672391
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Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Papio hamadryas |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
[123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 8.80 |
| CHEMBL2079586 | — | — | 1 | 7.82 |
| CHEMBL14391 | — | — | 1 | 7.06 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2079586 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL14391 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL370805 | COCAINE | IC50 | = | 221.0 | nM | 6.66 |