Assay Detail
Binding
CHEMBL672424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (low-affinity)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Retina |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.62 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45244 | PD-168,077 | — | 1 | 5.20 |
| CHEMBL554818 | — | — | 1 | 5.12 |
| CHEMBL544000 | — | — | 1 | 4.80 |
| CHEMBL542106 | — | — | 1 | 4.60 |
| CHEMBL545188 | — | — | 1 | 4.57 |
| CHEMBL553258 | — | — | 1 | 4.57 |
| CHEMBL543078 | — | — | 1 | 4.45 |
| CHEMBL538486 | — | — | 1 | 4.37 |
| CHEMBL544711 | — | — | 1 | 4.36 |
| CHEMBL544961 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45244 | PD-168,077 | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL554818 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL544000 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL542106 | — | Ki | = | 24900.0 | nM | 4.60 |
| CHEMBL545188 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL553258 | — | Ki | = | 26700.0 | nM | 4.57 |
| CHEMBL543078 | — | Ki | = | 35400.0 | nM | 4.45 |
| CHEMBL538486 | — | Ki | = | 43200.0 | nM | 4.37 |
| CHEMBL544711 | — | Ki | = | 43700.0 | nM | 4.36 |
| CHEMBL544961 | — | Ki | = | 64000.0 | nM | 4.19 |