Assay Detail
Binding
CHEMBL672485
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Binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.41 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25483 | — | — | 1 | 8.39 |
| CHEMBL10270 | — | — | 1 | 8.17 |
| CHEMBL286205 | — | — | 1 | 8.07 |
| CHEMBL280955 | — | — | 1 | 7.75 |
| CHEMBL283738 | — | — | 1 | 7.60 |
| CHEMBL275543 | — | — | 1 | 7.23 |
| CHEMBL285873 | — | — | 1 | 7.12 |
| CHEMBL10570 | — | — | 1 | 7.11 |
| CHEMBL418705 | — | — | 1 | 7.11 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.07 |
| CHEMBL24588 | — | — | 1 | 7.03 |
| CHEMBL10408 | — | — | 1 | 6.97 |
| CHEMBL26560 | — | — | 1 | 6.66 |
| CHEMBL267086 | — | — | 1 | - |
| CHEMBL566970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25483 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL10270 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL286205 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL280955 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL283738 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL275543 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL285873 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL10570 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL418705 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL24588 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL10408 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL26560 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL267086 | — | Ki | > | 339.0 | nM | - |
| CHEMBL566970 | — | Ki | > | 339.0 | nM | - |