Compound Detail
CHEMBL418705
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Basic Information
| ChEMBL ID | CHEMBL418705 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VRRJFCMGNMFNOE-KZUDCZAMSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
243.3
MW (Da)
2.99
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 7.31 | 7.31 | 49.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 7.11 | 7.11 | 77.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL3737 | Ki | 7.0 | 7.0 | 100.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 6.57 | 6.57 | 270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 49.0 | nM | 7.31 | Binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor s... | 8097537 |
| D(2) dopamine receptor | Ki | = | 77.0 | nM | 7.11 | Binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO... | 8097537 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 100.0 | nM | 7.0 | Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-... | 8097537 |
| D(2) dopamine receptor | Ki | = | 270.0 | nM | 6.57 | Binding affinity against [3H]raclopride-labeled dopamine receptor D2 in rat stri... | 8097537 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8097537 | 10.1021/jm00060a014 | Mus musculus | 20 |
| 8097537 | 10.1021/jm00060a014 | D(2) dopamine receptor | 3 |
| 8097537 | 10.1021/jm00060a014 | 5-hydroxytryptamine receptor 1A | 2 |
Data from ChEMBL 36 via Core Engine