Assay Detail
Binding
CHEMBL674062
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Binding affinity against [3H]raclopride-labeled dopamine receptor D2 in rat striatum.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.26 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10270 | — | — | 1 | 8.28 |
| CHEMBL286205 | — | — | 1 | 7.89 |
| CHEMBL280955 | — | — | 1 | 7.60 |
| CHEMBL24588 | — | — | 1 | 7.48 |
| CHEMBL10570 | — | — | 1 | 7.38 |
| CHEMBL10408 | — | — | 1 | 7.31 |
| CHEMBL25483 | — | — | 1 | 7.27 |
| CHEMBL280137 | — | — | 1 | 7.20 |
| CHEMBL284585 | — | — | 1 | 7.17 |
| CHEMBL24222 | — | — | 1 | 7.00 |
| CHEMBL285873 | — | — | 1 | 6.70 |
| CHEMBL275543 | — | — | 1 | 6.59 |
| CHEMBL418705 | — | — | 1 | 6.57 |
| CHEMBL26560 | — | — | 1 | - |
| CHEMBL568290 | — | — | 1 | - |
| CHEMBL25177 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL10677 | — | — | 1 | - |
| CHEMBL25691 | — | — | 1 | - |
| CHEMBL24532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10270 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL286205 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL280955 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL24588 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL10570 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL10408 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL25483 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL280137 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL284585 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL24222 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL285873 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL275543 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL418705 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL26560 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL568290 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL25177 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 1000.0 | nM | - |
| CHEMBL10677 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL25691 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL24532 | — | Ki | > | 10000.0 | nM | - |