Assay Detail
Binding
CHEMBL616562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.63 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10270 | — | — | 1 | 9.70 |
| CHEMBL26118 | — | — | 1 | 9.40 |
| CHEMBL24222 | — | — | 1 | 8.43 |
| CHEMBL418705 | — | — | 1 | 7.00 |
| CHEMBL10570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10270 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL26118 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL24222 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL418705 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL10570 | — | Ki | > | 333.0 | nM | - |