Assay Detail
Binding
CHEMBL672592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at dopamine transporter in rat striatum by [3H]WIN-35428 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.39 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35239 | — | — | 1 | 8.44 |
| CHEMBL159128 | — | — | 1 | 8.35 |
| CHEMBL369406 | — | — | 1 | 8.15 |
| CHEMBL110530 | — | — | 1 | 8.03 |
| CHEMBL433733 | — | — | 1 | 8.00 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.97 |
| CHEMBL20648 | — | — | 1 | 7.76 |
| CHEMBL39262 | — | — | 1 | 7.71 |
| CHEMBL173160 | — | — | 1 | 7.63 |
| CHEMBL353643 | — | — | 1 | 7.58 |
| CHEMBL35005 | — | — | 1 | 7.49 |
| CHEMBL424005 | — | — | 1 | 7.46 |
| CHEMBL173812 | — | — | 1 | 7.18 |
| CHEMBL174062 | — | — | 1 | 7.03 |
| CHEMBL353532 | — | — | 1 | 6.67 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.58 |
| CHEMBL369693 | — | — | 1 | 6.53 |
| CHEMBL176626 | — | — | 1 | 6.12 |
| CHEMBL175334 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35239 | — | IC50 | = | 3.67 | nM | 8.44 |
| CHEMBL159128 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL369406 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL110530 | — | IC50 | = | 9.37 | nM | 8.03 |
| CHEMBL433733 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL20648 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL39262 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL173160 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL353643 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL35005 | — | IC50 | = | 32.1 | nM | 7.49 |
| CHEMBL424005 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL173812 | — | IC50 | = | 65.3 | nM | 7.18 |
| CHEMBL174062 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL353532 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL370805 | COCAINE | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL369693 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL176626 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL175334 | — | IC50 | = | 2156.0 | nM | 5.67 |