Assay Detail
Functional
CHEMBL672680
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Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.66 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86931 | — | — | 1 | 8.71 |
| CHEMBL291143 | — | — | 1 | 8.29 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.52 |
| CHEMBL317741 | — | — | 1 | 6.31 |
| CHEMBL407489 | — | — | 1 | 6.16 |
| CHEMBL101617 | — | — | 1 | 6.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.30 |
| CHEMBL43345 | — | — | 1 | 5.00 |
| CHEMBL299161 | — | — | 1 | - |
| CHEMBL418791 | — | — | 1 | - |
| CHEMBL49634 | — | — | 1 | - |
| CHEMBL317647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86931 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL291143 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL25856 | DIHYDREXIDINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL317741 | — | EC50 | = | 491.0 | nM | 6.31 |
| CHEMBL407489 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL101617 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL59 | DOPAMINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL43345 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL299161 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL418791 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL49634 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL317647 | — | EC50 | > | 10000.0 | nM | - |