Assay Detail
Binding
CHEMBL672685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.07 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34095 | — | — | 1 | 8.37 |
| CHEMBL35354 | — | — | 1 | 8.29 |
| CHEMBL284473 | — | — | 1 | 8.09 |
| CHEMBL32145 | — | — | 1 | 8.00 |
| CHEMBL288090 | — | — | 1 | 7.71 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.30 |
| CHEMBL286080 | SKF-38393 | — | 1 | 6.72 |
| CHEMBL286424 | — | — | 1 | 5.73 |
| CHEMBL286120 | — | — | 1 | 5.55 |
| CHEMBL284746 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34095 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL35354 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL284473 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL32145 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL288090 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL24077 | (R)-SKF-38393 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL286080 | SKF-38393 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL286424 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL286120 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL284746 | — | IC50 | = | 10700.0 | nM | 4.97 |