Assay Detail
Binding
CHEMBL672699
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In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.20 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539544 | — | — | 1 | 6.89 |
| CHEMBL541842 | — | — | 1 | 6.87 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.77 |
| CHEMBL543613 | — | — | 1 | 6.53 |
| CHEMBL308480 | — | — | 1 | 6.49 |
| CHEMBL310734 | — | — | 1 | 6.42 |
| CHEMBL544319 | — | — | 1 | 6.37 |
| CHEMBL558817 | — | — | 1 | 6.25 |
| CHEMBL95098 | — | — | 1 | 5.88 |
| CHEMBL96781 | — | — | 1 | 5.87 |
| CHEMBL542428 | — | — | 1 | 5.87 |
| CHEMBL310153 | — | — | 1 | 5.87 |
| CHEMBL87717 | — | — | 1 | 5.55 |
| CHEMBL545488 | — | — | 1 | 5.51 |
| CHEMBL540822 | — | — | 1 | 5.27 |
| CHEMBL544318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539544 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL541842 | — | Ki | = | 134.9 | nM | 6.87 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL543613 | — | Ki | = | 295.12 | nM | 6.53 |
| CHEMBL308480 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL310734 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL544319 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL558817 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL95098 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL96781 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL542428 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL310153 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL87717 | — | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL545488 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL540822 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL544318 | — | Ki | < | 10000.0 | nM | - |