Assay Detail
Binding
CHEMBL672802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.69 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15136 | — | — | 1 | 8.96 |
| CHEMBL155596 | — | — | 1 | 8.52 |
| CHEMBL155613 | — | — | 1 | 6.96 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15136 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL155596 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL155613 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1303 | ROTIGOTINE | Ki | = | 500.0 | nM | 6.30 |