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Assay Detail

CHEMBL672874

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Functional
Evaluated for contraction of dog saphenous vein
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Canis lupus familiaris
Tissue Saphenous vein
Confidence 1 — Organism
Curated By Expert

Target

Canis familiaris (CHEMBL373)
Type ORGANISM
Organism Canis lupus familiaris

Publication

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs.
Bhagwat SS, Gude C, Boswell C, Contardo N, Cohen DS, Dotson R, Mathis J, Lee W, Furness P, Zoganas H.
J Med Chem (1992) 35 : 4373 -4383
PubMed 1447738 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 14 8.60 9.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL341686 1 9.57
CHEMBL63904 1 9.40
CHEMBL138743 1 9.33
CHEMBL136880 1 9.22
CHEMBL134365 1 9.00
CHEMBL65414 1 8.90
CHEMBL136934 1 8.83
CHEMBL435590 1 8.81
CHEMBL137187 1 8.73
CHEMBL345105 1 8.43
CHEMBL134580 1 8.26
CHEMBL136371 1 8.13
CHEMBL136918 1 7.46
CHEMBL280728 RIDOGREL 2.0 1 6.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL341686 Kd = 0.2692 nM 9.57
CHEMBL63904 Kd = 0.3981 nM 9.40
CHEMBL138743 Kd = 0.4677 nM 9.33
CHEMBL136880 Kd = 0.6026 nM 9.22
CHEMBL134365 Kd = 1.0 nM 9.00
CHEMBL65414 Kd = 1.259 nM 8.90
CHEMBL136934 Kd = 1.479 nM 8.83
CHEMBL435590 Kd = 1.549 nM 8.81
CHEMBL137187 Kd = 1.862 nM 8.73
CHEMBL345105 Kd = 3.715 nM 8.43
CHEMBL134580 Kd = 5.495 nM 8.26
CHEMBL136371 Kd = 7.413 nM 8.13
CHEMBL136918 Kd = 34.67 nM 7.46
CHEMBL280728 RIDOGREL Kd = 446.68 nM 6.35