Assay Detail
Binding
CHEMBL672934
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In vitro binding affinity towards dopamine receptor was determined in bovine anterior pituitary membrane using [3H]dihydroergocriptine as the radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.14 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333795 | — | — | 1 | 7.40 |
| CHEMBL1275 | PERGOLIDE MESYLATE | 4.0 | 1 | 7.30 |
| CHEMBL148600 | — | — | 1 | 6.52 |
| CHEMBL347326 | — | — | 1 | 6.30 |
| CHEMBL330997 | — | — | 1 | 5.60 |
| CHEMBL147244 | — | — | 1 | 5.52 |
| CHEMBL359414 | — | — | 1 | 5.32 |
| CHEMBL121653 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333795 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1275 | PERGOLIDE MESYLATE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL148600 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL347326 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL330997 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL147244 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL359414 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL121653 | — | IC50 | = | 7000.0 | nM | 5.16 |