Assay Detail
Binding
CHEMBL672936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against dopamine receptor from calf caudate using [3H]spiperone as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.97 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | 2.0 | 1 | 7.60 |
| CHEMBL2218861 | QUINAGOLIDE | 4.0 | 1 | 7.32 |
| CHEMBL330849 | — | — | 1 | 7.22 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 6.84 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2218861 | QUINAGOLIDE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL330849 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 1350.0 | nM | 5.87 |