Assay Detail
Binding
CHEMBL673000
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Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.45 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.04 |
| CHEMBL161122 | — | — | 1 | 8.82 |
| CHEMBL62429 | — | — | 1 | 8.74 |
| CHEMBL161668 | — | — | 1 | 8.64 |
| CHEMBL161973 | — | — | 1 | 8.59 |
| CHEMBL350287 | — | — | 1 | 8.52 |
| CHEMBL23403 | — | — | 1 | 8.33 |
| CHEMBL345223 | — | — | 1 | 8.30 |
| CHEMBL161972 | — | — | 1 | 8.26 |
| CHEMBL161417 | — | — | 1 | 8.18 |
| CHEMBL159842 | — | — | 1 | 8.11 |
| CHEMBL161177 | — | — | 1 | 8.10 |
| CHEMBL161721 | — | — | 1 | 7.96 |
| CHEMBL350997 | — | — | 1 | 7.96 |
| CHEMBL293904 | — | — | 1 | 7.92 |
| CHEMBL159292 | — | — | 1 | 7.77 |
| CHEMBL161361 | — | — | 1 | 7.77 |
| CHEMBL303334 | — | — | 1 | 7.58 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.50 |
| CHEMBL161418 | — | — | 1 | 7.24 |
| CHEMBL350276 | — | — | 1 | 6.96 |
| CHEMBL414454 | — | — | 1 | 6.82 |
| CHEMBL450277 | — | — | 1 | 6.73 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 6.68 |
| CHEMBL22242 | REMOXIPRIDE | 4.0 | 1 | 5.80 |
| CHEMBL308129 | — | — | 1 | 5.54 |
| CHEMBL159945 | — | — | 1 | 5.20 |
| CHEMBL349416 | — | — | 1 | 4.89 |
| CHEMBL25547 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL161122 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL62429 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL161668 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL161973 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL350287 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL23403 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL345223 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL161972 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL161417 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL159842 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL161177 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL161721 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL350997 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL293904 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL159292 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL161361 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL303334 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL161418 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL350276 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL414454 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL450277 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL267044 | LEVOSULPIRIDE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL22242 | REMOXIPRIDE | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL308129 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL159945 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL349416 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL25547 | — | IC50 | = | 59900.0 | nM | 4.22 |