Assay Detail
Binding
CHEMBL673002
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Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranes
28
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.49 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.96 |
| CHEMBL44558 | — | — | 1 | 8.70 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.51 |
| CHEMBL42242 | — | — | 1 | 8.48 |
| CHEMBL41980 | — | — | 1 | 7.85 |
| CHEMBL42309 | — | — | 1 | 7.85 |
| CHEMBL44501 | — | — | 4 | 7.71 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 7.55 |
| CHEMBL41420 | — | — | 1 | 7.09 |
| CHEMBL43071 | — | — | 1 | 6.96 |
| CHEMBL295359 | — | — | 1 | 6.92 |
| CHEMBL42237 | — | — | 1 | 6.74 |
| CHEMBL42909 | — | — | 1 | 6.73 |
| CHEMBL40542 | — | — | 1 | 6.38 |
| CHEMBL44257 | — | — | 1 | 6.24 |
| CHEMBL42291 | — | — | 1 | 5.91 |
| CHEMBL43762 | — | — | 4 | 5.82 |
| CHEMBL288531 | — | — | 1 | 5.53 |
| CHEMBL42047 | — | — | 1 | 5.42 |
| CHEMBL288765 | — | — | 1 | 5.33 |
| CHEMBL44528 | — | — | 1 | 5.08 |
| CHEMBL43930 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL44558 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL42242 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL41980 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL42309 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL44501 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL44501 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL41420 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL43071 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL295359 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL42237 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL42909 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL40542 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL44257 | — | IC50 | = | 572.0 | nM | 6.24 |
| CHEMBL42291 | — | IC50 | = | 1242.0 | nM | 5.91 |
| CHEMBL43762 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL43762 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL288531 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL42047 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL288765 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL44528 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL43762 | — | IC50 | = | 10210.0 | nM | 4.99 |
| CHEMBL44501 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL44501 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL43930 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL43762 | — | IC50 | = | 65300.0 | nM | 4.18 |