Assay Detail
Binding
CHEMBL673004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiroperidol (0.5 nM) binding to dopamine receptor from rat striatal membrane.
33
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.40 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542376 | — | — | 1 | 8.24 |
| CHEMBL553243 | — | — | 1 | 8.22 |
| CHEMBL417401 | — | — | 1 | 8.17 |
| CHEMBL539257 | — | — | 1 | 8.12 |
| CHEMBL542375 | — | — | 1 | 8.07 |
| CHEMBL545436 | — | — | 1 | 8.03 |
| CHEMBL57241 | FLUTROLINE | 2.0 | 1 | 7.92 |
| CHEMBL545209 | — | — | 1 | 7.92 |
| CHEMBL299903 | — | — | 1 | 7.92 |
| CHEMBL543095 | — | — | 1 | 7.89 |
| CHEMBL543327 | — | — | 1 | 7.89 |
| CHEMBL540282 | — | — | 1 | 7.85 |
| CHEMBL294488 | — | — | 1 | 7.85 |
| CHEMBL544039 | — | — | 1 | 7.72 |
| CHEMBL60634 | — | — | 2 | 7.66 |
| CHEMBL57351 | — | — | 2 | 7.60 |
| CHEMBL544036 | — | — | 1 | 7.60 |
| CHEMBL294025 | — | — | 1 | 7.58 |
| CHEMBL56580 | — | — | 1 | 7.46 |
| CHEMBL538242 | — | — | 1 | 7.35 |
| CHEMBL552625 | — | — | 1 | 7.27 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 7.21 |
| CHEMBL543569 | — | — | 1 | 7.17 |
| CHEMBL553953 | — | — | 1 | 7.08 |
| CHEMBL542858 | — | — | 1 | 6.85 |
| CHEMBL292214 | — | — | 1 | 6.66 |
| CHEMBL59582 | — | — | 1 | 6.46 |
| CHEMBL543325 | — | — | 1 | 6.00 |
| CHEMBL55545 | — | — | 1 | 5.50 |
| CHEMBL538990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542376 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL553243 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL417401 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL539257 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL542375 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL545436 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL545209 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL57241 | FLUTROLINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL299903 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL543095 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL543327 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL540282 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL294488 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL544039 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL60634 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL57351 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL544036 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL294025 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL56580 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL538242 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL552625 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL47050 | PENFLURIDOL | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL543569 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL553953 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL542858 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL292214 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL59582 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL57351 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL543325 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60634 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL55545 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL538990 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL544741 | — | IC50 | > | 320.0 | nM | - |