Assay Detail
Binding
CHEMBL673083
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In vitro binding affinity at human Dopamine receptor D2 (long) by [3H]spiroperidol displacement.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.73 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328283 | — | — | 1 | 6.58 |
| CHEMBL329228 | — | — | 1 | 6.55 |
| CHEMBL420067 | — | — | 1 | 6.01 |
| CHEMBL93403 | — | — | 1 | 5.72 |
| CHEMBL315879 | — | — | 1 | 5.63 |
| CHEMBL327245 | — | — | 1 | 5.59 |
| CHEMBL318747 | — | — | 1 | 5.56 |
| CHEMBL2112375 | — | — | 1 | 5.50 |
| CHEMBL321557 | — | — | 1 | 5.47 |
| CHEMBL92713 | — | — | 1 | 5.40 |
| CHEMBL330470 | — | — | 1 | 5.40 |
| CHEMBL96462 | — | — | 1 | 5.30 |
| CHEMBL92121 | — | — | 1 | - |
| CHEMBL96322 | — | — | 1 | - |
| CHEMBL92411 | — | — | 1 | - |
| CHEMBL94265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328283 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL329228 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL420067 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL93403 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL315879 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL327245 | — | Ki | = | 2550.0 | nM | 5.59 |
| CHEMBL318747 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL2112375 | — | Ki | = | 3180.0 | nM | 5.50 |
| CHEMBL321557 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL92713 | — | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL330470 | — | Ki | = | 3960.0 | nM | 5.40 |
| CHEMBL96462 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL92121 | — | Ki | > | 850.0 | nM | - |
| CHEMBL96322 | — | Ki | > | 850.0 | nM | - |
| CHEMBL92411 | — | Ki | > | 850.0 | nM | - |
| CHEMBL94265 | — | Ki | > | 850.0 | nM | - |