Assay Detail
Binding
CHEMBL673105
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Inhibition of Human Leukocyte Elastase (HLE)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of orally active, non-peptidic inhibitors of human leukocyte elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.77 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276307 | — | — | 1 | 9.03 |
| CHEMBL282694 | — | — | 1 | 8.74 |
| CHEMBL11391 | — | — | 1 | 8.35 |
| CHEMBL280916 | — | — | 1 | 8.24 |
| CHEMBL11403 | — | — | 1 | 8.18 |
| CHEMBL275043 | — | — | 1 | 8.10 |
| CHEMBL11098 | — | — | 1 | 8.09 |
| CHEMBL277905 | — | — | 1 | 7.89 |
| CHEMBL279250 | — | — | 1 | 7.75 |
| CHEMBL11336 | — | — | 1 | 7.40 |
| CHEMBL428848 | — | — | 1 | 7.00 |
| CHEMBL2371666 | — | — | 1 | 6.68 |
| CHEMBL25490 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276307 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL282694 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL11391 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL280916 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL11403 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL275043 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL11098 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL277905 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL279250 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL11336 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL428848 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL2371666 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL25490 | — | Ki | = | 2800.0 | nM | 5.55 |