Compound Detail
CHEMBL280916
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CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccc(C(=O)O)cc2)c1=O)C(=O)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL280916 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ROYDASXTYMKFDZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
573.5
MW (Da)
4.23
ALogP
7
HBA
3
HBD
143.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neutrophil elastase CHEMBL248 | Ki | 8.24 | 8.24 | 5.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neutrophil elastase | Ki | = | 5.7 | nM | 8.24 | Inhibition of Human Leukocyte Elastase (HLE) | 8176703 |
| Neutrophil elastase | Ki | = | 5.7 | nM | 8.24 | Binding affinity against human leukocyte elastase (HLE) enzyme | 7932559 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7932559 | 10.1021/jm00046a016 | No relevant target | 4 |
| 8176703 | 10.1021/jm00035a004 | Neutrophil elastase | 1 |
| 8176703 | 10.1021/jm00035a004 | Cricetinae gen. sp. | 1 |
| 7932559 | 10.1021/jm00046a016 | Neutrophil elastase | 1 |
| 7932559 | 10.1021/jm00046a016 | Cricetinae gen. sp. | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine