Assay Detail
Binding
CHEMBL673203
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Displacement of [3H]WIN-35428(0.5 nM) from Dopamine transporter
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and ligand binding of tropane ring analogues of paroxetine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.73 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606881 | — | — | 1 | 8.52 |
| CHEMBL88301 | — | — | 2 | 8.41 |
| CHEMBL312977 | — | — | 1 | 7.56 |
| CHEMBL314878 | — | — | 1 | 6.85 |
| CHEMBL606825 | — | — | 1 | 6.76 |
| CHEMBL606927 | — | — | 1 | 6.53 |
| CHEMBL606877 | — | — | 1 | 6.51 |
| CHEMBL87616 | — | — | 2 | 6.39 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 6.21 |
| CHEMBL606828 | — | — | 1 | 5.98 |
| CHEMBL606826 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606881 | — | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL88301 | — | IC50 | = | 3.86 | nM | 8.41 |
| CHEMBL312977 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL314878 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL606825 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL606927 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL606877 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL87616 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL490 | PAROXETINE | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL87616 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL606828 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL88301 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL606826 | — | IC50 | = | 1500.0 | nM | 5.82 |