Assay Detail
Binding
CHEMBL673226
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Inhibition of Human Endothelin B receptor expressed in CHO Cells.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.64 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105490 | — | — | 1 | 5.77 |
| CHEMBL29422 | — | — | 1 | 5.36 |
| CHEMBL106749 | — | — | 1 | 4.92 |
| CHEMBL322674 | — | — | 1 | 4.92 |
| CHEMBL24461 | — | — | 1 | 4.73 |
| CHEMBL104848 | — | — | 1 | 4.70 |
| CHEMBL319924 | — | — | 1 | 4.47 |
| CHEMBL107574 | — | — | 1 | 4.11 |
| CHEMBL319036 | — | — | 1 | 4.03 |
| CHEMBL104172 | — | — | 1 | 4.03 |
| CHEMBL104223 | — | — | 1 | 4.00 |
| CHEMBL106846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105490 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL29422 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL106749 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL322674 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL24461 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL104848 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL319924 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL107574 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL319036 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL104172 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL104223 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL106846 | — | Ki | = | 110000.0 | nM | - |