Compound Detail
CHEMBL29422
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Basic Information
| ChEMBL ID | CHEMBL29422 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XAHBFCGXCQNZHI-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
466.5
MW (Da)
4.05
ALogP
7
HBA
2
HBD
127.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | Ki | 9.7 | 9.7 | 0.2 | 2 |
| Endothelin receptor type B CHEMBL1785 | Ki | 5.36 | 5.36 | 4400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | Ki | = | 0.2 | nM | 9.7 | Inhibitory activity against human endothelin A receptor expressed in CHO cells | 12502366 |
| Endothelin-1 receptor | Ki | = | 0.2 | nM | 9.7 | Inhibition of Human Endothelin A receptor expressed in CHO Cells. | 10956219 |
| Endothelin receptor type B | Ki | = | 4400.0 | nM | 5.36 | Inhibitory activity against human endothelin B receptor expressed in CHO cells | 12502366 |
| Endothelin receptor type B | Ki | = | 4400.0 | nM | 5.36 | Inhibition of Human Endothelin B receptor expressed in CHO Cells. | 10956219 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12502366 | 10.1021/jm020289q | Endothelin-1 receptor | 1 |
| 12502366 | 10.1021/jm020289q | Oryctolagus cuniculus | 1 |
| 12502366 | 10.1021/jm020289q | Endothelin receptor type B | 1 |
| 12502366 | 10.1021/jm020289q | Homo sapiens | 1 |
| 12502366 | 10.1021/jm020289q | No relevant target | 1 |
| 10956219 | 10.1021/jm000105c | Endothelin-1 receptor | 1 |
| 10956219 | 10.1021/jm000105c | Oryctolagus cuniculus | 1 |
| 10956219 | 10.1021/jm000105c | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine