Assay Detail
Binding
CHEMBL673249
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In vitro binding affinity on D3 receptor is inhibition of binding of [125I]- NCQ 298 to Sf9 cells infected with recombinant baculovirus
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Spodoptera frugiperda |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.99 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308524 | IOXIPRIDE | — | 1 | 9.80 |
| CHEMBL2112607 | — | — | 1 | 9.68 |
| CHEMBL124612 | — | — | 1 | 9.35 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.88 |
| CHEMBL340471 | — | — | 1 | 8.23 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308524 | IOXIPRIDE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL2112607 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL124612 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL267930 | SPIPERONE | Ki | = | 1.31 | nM | 8.88 |
| CHEMBL340471 | — | Ki | = | 5.91 | nM | 8.23 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 10.4 | nM | 7.98 |