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Assay Detail

CHEMBL673316

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration inhibiting the specific binding of [3H]naloxone by 50% in the absence of NaCl
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Dopamine receptor (CHEMBL2093868)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.
Imhof R, Kyburz E, Daly JJ.
J Med Chem (1984) 27 : 165 -175
PubMed 6198519 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.71 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48264 1 8.49
CHEMBL555325 1 8.32
CHEMBL556578 MORPHINE HYDROCHLORIDE 3.0 1 8.27
CHEMBL542366 1 7.62
CHEMBL554207 2 7.60
CHEMBL559199 1 7.22
CHEMBL543082 1 6.89
CHEMBL556052 1 6.82
CHEMBL299098 1 5.82
CHEMBL554423 2 5.52
CHEMBL49665 2 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48264 IC50 = 3.2 nM 8.49
CHEMBL555325 IC50 = 4.8 nM 8.32
CHEMBL556578 MORPHINE HYDROCHLORIDE IC50 = 5.4 nM 8.27
CHEMBL542366 IC50 = 24.0 nM 7.62
CHEMBL554207 IC50 = 25.0 nM 7.60
CHEMBL559199 IC50 = 60.0 nM 7.22
CHEMBL543082 IC50 = 130.0 nM 6.89
CHEMBL556052 IC50 = 150.0 nM 6.82
CHEMBL299098 IC50 = 1500.0 nM 5.82
CHEMBL554207 IC50 = 2750.0 nM 5.56
CHEMBL554423 IC50 = 3000.0 nM 5.52
CHEMBL554423 IC50 = 3900.0 nM 5.41
CHEMBL49665 IC50 = 5400.0 nM 5.27
CHEMBL49665 IC50 = 8000.0 nM 5.10