Assay Detail
Binding
CHEMBL673317
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Concentration inhibiting the specific binding of [3H]naloxone by 50% in the presence of NaCl
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.35 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48264 | — | — | 1 | 7.57 |
| CHEMBL559199 | — | — | 1 | 7.40 |
| CHEMBL555325 | — | — | 1 | 7.28 |
| CHEMBL554207 | — | — | 2 | 7.24 |
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | 3.0 | 1 | 6.92 |
| CHEMBL542366 | — | — | 1 | 6.66 |
| CHEMBL556052 | — | — | 1 | 6.55 |
| CHEMBL299098 | — | — | 1 | 6.17 |
| CHEMBL543082 | — | — | 1 | 5.85 |
| CHEMBL554423 | — | — | 2 | 5.52 |
| CHEMBL49665 | — | — | 2 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48264 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL559199 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL555325 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL554207 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL542366 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL556052 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL299098 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL554207 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL543082 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL554423 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL554423 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL49665 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL49665 | — | IC50 | = | 11300.0 | nM | 4.95 |