Assay Detail
Binding
CHEMBL673344
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Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.00 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.92 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.46 |
| CHEMBL51017 | — | — | 1 | 7.04 |
| CHEMBL407489 | — | — | 1 | 6.92 |
| CHEMBL299161 | — | — | 1 | 6.19 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.10 |
| CHEMBL299430 | — | — | 1 | - |
| CHEMBL49634 | — | — | 1 | - |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | - |
| CHEMBL43345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL24077 | (R)-SKF-38393 | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL51017 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL407489 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL299161 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL59 | DOPAMINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL299430 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL49634 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL240773 | QUINPIROLE | IC50 | > | 30000.0 | nM | - |
| CHEMBL43345 | — | IC50 | > | 5000.0 | nM | - |