Assay Detail
Binding
CHEMBL673448
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Binding affinity evaluated for the displacement of [3H]-spiperone against human dopamine receptor D3
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.40 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7506 | — | — | 1 | 6.64 |
| CHEMBL268799 | — | — | 1 | 6.37 |
| CHEMBL269202 | — | — | 1 | 6.25 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.02 |
| CHEMBL7442 | — | — | 1 | 5.96 |
| CHEMBL273860 | — | — | 1 | 5.80 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.30 |
| CHEMBL268558 | — | — | 1 | 5.28 |
| CHEMBL7686 | — | — | 1 | 5.28 |
| CHEMBL268190 | — | — | 1 | 5.26 |
| CHEMBL267853 | — | — | 1 | 5.18 |
| CHEMBL7508 | — | — | 1 | 5.17 |
| CHEMBL269576 | — | — | 1 | 4.68 |
| CHEMBL267014 | L-745870 | — | 1 | 4.54 |
| CHEMBL7505 | — | — | 1 | 4.47 |
| CHEMBL7441 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7506 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL268799 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL269202 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL42 | CLOZAPINE | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL7442 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL273860 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL7927 | FAUC 113 | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL268558 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL7686 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL268190 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL267853 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL7508 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL269576 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL267014 | L-745870 | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL7505 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL7441 | — | Ki | = | 61000.0 | nM | 4.21 |