Assay Detail
Binding
CHEMBL673449
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Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.30 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51536 | — | — | 1 | 7.31 |
| CHEMBL296953 | — | — | 1 | 7.18 |
| CHEMBL51023 | — | — | 1 | 6.76 |
| CHEMBL298763 | — | — | 1 | 6.75 |
| CHEMBL49231 | — | — | 1 | 6.57 |
| CHEMBL295094 | — | — | 1 | 6.44 |
| CHEMBL300956 | — | — | 1 | 6.42 |
| CHEMBL298166 | — | — | 1 | 6.33 |
| CHEMBL49876 | — | — | 1 | 6.22 |
| CHEMBL48819 | — | — | 1 | 5.84 |
| CHEMBL49502 | — | — | 1 | 5.64 |
| CHEMBL296506 | — | — | 1 | 5.61 |
| CHEMBL48807 | — | — | 1 | 5.61 |
| CHEMBL45244 | PD-168,077 | — | 1 | 5.55 |
| CHEMBL423659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51536 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL296953 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL51023 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL298763 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL49231 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL295094 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL300956 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL298166 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL49876 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL48819 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL49502 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL296506 | — | Ki | = | 2480.0 | nM | 5.61 |
| CHEMBL48807 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL45244 | PD-168,077 | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL423659 | — | Ki | > | 3000.0 | nM | - |