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Compound Detail

CHEMBL295094

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O=C(NCN1CCN(c2ccccc2Cl)CC1)c1cccc(Cl)c1

Basic Information

ChEMBL ID CHEMBL295094
Phase Preclinical
Structure Type MOL
InChI Key OFDQLTVLCXEIAI-UHFFFAOYSA-N
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

364.3
MW (Da)
3.50
ALogP
3
HBA
1
HBD
35.6
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19Cl2N3O
MW 364.28
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.76

Activity Summary

Ki 6 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 7.39 7.39 40.7 2
D(2) dopamine receptor
CHEMBL217
Ki 6.44 6.03 363.1 2
D(3) dopamine receptor
CHEMBL234
Ki 6.44 6.44 364.0 1
Unchecked
CHEMBL612545
Ki 5.62 5.62 2398.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9191952 10.1021/jm970021c D(4) dopamine receptor 1
9191952 10.1021/jm970021c D(3) dopamine receptor 1
9191952 10.1021/jm970021c D(2) dopamine receptor 1
15808487 10.1016/j.bmcl.2005.02.012 D(4) dopamine receptor 1
15808487 10.1016/j.bmcl.2005.02.012 D(2) dopamine receptor 1
15808487 10.1016/j.bmcl.2005.02.012 Unchecked 1

Data from ChEMBL 36 via Core Engine