Assay Detail
Binding
CHEMBL673451
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Inhibition of epidermal growth factor receptor (EGFR) autophosphorylation in A431 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126623 | — | — | 1 | 8.09 |
| CHEMBL53428 | — | — | 1 | 7.85 |
| CHEMBL54400 | — | — | 1 | 7.80 |
| CHEMBL128987 | — | — | 1 | 7.44 |
| CHEMBL52076 | — | — | 1 | 6.96 |
| CHEMBL126372 | — | — | 1 | 6.64 |
| CHEMBL127086 | — | — | 1 | 4.94 |
| CHEMBL128467 | — | — | 1 | - |
| CHEMBL339416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126623 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL53428 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL54400 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL128987 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL52076 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL126372 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL127086 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL128467 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL339416 | — | IC50 | > | 1000.0 | nM | - |