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Assay Detail

CHEMBL673465

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration inhibiting the specific binding of [3H]spiroperidol by 50%
26
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Dopamine receptor (CHEMBL2093868)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.
Imhof R, Kyburz E, Daly JJ.
J Med Chem (1984) 27 : 165 -175
PubMed 6198519 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.38 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1255588 1 8.70
CHEMBL554423 2 7.58
CHEMBL552806 3 7.55
CHEMBL71 CHLORPROMAZINE 4.0 1 7.51
CHEMBL49355 1 7.32
CHEMBL558780 1 7.30
CHEMBL554207 2 6.92
CHEMBL541292 1 6.69
CHEMBL559019 1 6.55
CHEMBL556052 1 6.44
CHEMBL544728 1 6.18
CHEMBL538742 1 6.16
CHEMBL543082 1 5.98
CHEMBL49665 2 5.85
CHEMBL555384 1 5.83
CHEMBL555325 1 5.66
CHEMBL559199 1 5.66
CHEMBL545660 1 5.54
CHEMBL545423 1 5.52
CHEMBL6066837 (-)-BUTACLAMOL 1 5.40
CHEMBL542366 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1255588 IC50 = 2.0 nM 8.70
CHEMBL554423 IC50 = 26.0 nM 7.58
CHEMBL552806 IC50 = 28.0 nM 7.55
CHEMBL71 CHLORPROMAZINE IC50 = 31.0 nM 7.51
CHEMBL49355 IC50 = 48.0 nM 7.32
CHEMBL558780 IC50 = 50.0 nM 7.30
CHEMBL552806 IC50 = 63.0 nM 7.20
CHEMBL554207 IC50 = 120.0 nM 6.92
CHEMBL541292 IC50 = 204.0 nM 6.69
CHEMBL554207 IC50 = 209.0 nM 6.68
CHEMBL559019 IC50 = 283.0 nM 6.55
CHEMBL556052 IC50 = 360.0 nM 6.44
CHEMBL544728 IC50 = 655.0 nM 6.18
CHEMBL538742 IC50 = 695.0 nM 6.16
CHEMBL552806 IC50 = 740.0 nM 6.13
CHEMBL543082 IC50 = 1050.0 nM 5.98
CHEMBL49665 IC50 = 1400.0 nM 5.85
CHEMBL555384 IC50 = 1480.0 nM 5.83
CHEMBL555325 IC50 = 2200.0 nM 5.66
CHEMBL559199 IC50 = 2200.0 nM 5.66
CHEMBL49665 IC50 = 2540.0 nM 5.59
CHEMBL545660 IC50 = 2920.0 nM 5.54
CHEMBL545423 IC50 = 3000.0 nM 5.52
CHEMBL6066837 (-)-BUTACLAMOL IC50 = 4000.0 nM 5.40
CHEMBL542366 IC50 = 5000.0 nM 5.30
CHEMBL554423 IC50 = 23000.0 nM 4.64