Assay Detail
Binding
CHEMBL673645
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Effective concentration against human Dopamine receptor D4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.17 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77563 | — | — | 1 | 9.00 |
| CHEMBL309372 | — | — | 1 | 8.25 |
| CHEMBL77708 | — | — | 1 | 8.00 |
| CHEMBL77395 | — | — | 1 | 7.50 |
| CHEMBL310843 | — | — | 1 | 6.81 |
| CHEMBL267014 | L-745870 | — | 1 | 5.65 |
| CHEMBL80469 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77563 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL309372 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL77708 | — | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL77395 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL310843 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL267014 | L-745870 | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL80469 | — | EC50 | = | 10000.0 | nM | 5.00 |