Assay Detail
Functional
CHEMBL673659
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Potency in cellular transactivation assay utilizing HEK293 cells stably co-transfected with human estrogen receptor beta and the alkaline phosphatase reporter gene
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.67 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329902 | — | — | 1 | 8.14 |
| CHEMBL327320 | — | — | 1 | 7.40 |
| CHEMBL539927 | — | — | 1 | 7.28 |
| CHEMBL92660 | — | — | 1 | 7.19 |
| CHEMBL92027 | — | — | 1 | 7.18 |
| CHEMBL94225 | — | — | 1 | 7.17 |
| CHEMBL329849 | — | — | 1 | 7.17 |
| CHEMBL94116 | — | — | 1 | 6.92 |
| CHEMBL92635 | — | — | 1 | 6.88 |
| CHEMBL93705 | — | — | 1 | 6.80 |
| CHEMBL328716 | — | — | 1 | 6.75 |
| CHEMBL93793 | — | — | 1 | 6.70 |
| CHEMBL71584 | — | — | 1 | 6.62 |
| CHEMBL91807 | — | — | 1 | 6.61 |
| CHEMBL94030 | — | — | 1 | 6.29 |
| CHEMBL327471 | — | — | 1 | 6.16 |
| CHEMBL441457 | — | — | 1 | 5.99 |
| CHEMBL94170 | — | — | 1 | 5.84 |
| CHEMBL93546 | — | — | 1 | 5.81 |
| CHEMBL90072 | — | — | 1 | 5.62 |
| CHEMBL420623 | — | — | 1 | 5.52 |
| CHEMBL92720 | — | — | 1 | - |
| CHEMBL420068 | — | — | 1 | - |
| CHEMBL420611 | — | — | 1 | - |
| CHEMBL92335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329902 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL327320 | — | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL539927 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL92660 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL92027 | — | IC50 | = | 65.3 | nM | 7.18 |
| CHEMBL94225 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL329849 | — | IC50 | = | 68.3 | nM | 7.17 |
| CHEMBL94116 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL92635 | — | IC50 | = | 131.8 | nM | 6.88 |
| CHEMBL93705 | — | IC50 | = | 157.4 | nM | 6.80 |
| CHEMBL328716 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL93793 | — | IC50 | = | 199.8 | nM | 6.70 |
| CHEMBL71584 | — | IC50 | = | 238.8 | nM | 6.62 |
| CHEMBL91807 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL94030 | — | IC50 | = | 516.1 | nM | 6.29 |
| CHEMBL327471 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL441457 | — | IC50 | = | 1013.0 | nM | 5.99 |
| CHEMBL94170 | — | IC50 | = | 1455.0 | nM | 5.84 |
| CHEMBL93546 | — | IC50 | = | 1555.0 | nM | 5.81 |
| CHEMBL90072 | — | IC50 | = | 2369.0 | nM | 5.62 |
| CHEMBL420623 | — | IC50 | = | 3021.0 | nM | 5.52 |
| CHEMBL92720 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL420068 | — | IC50 | - | nM | - | |
| CHEMBL420611 | — | IC50 | - | nM | - | |
| CHEMBL92335 | — | IC50 | - | nM | - |