Assay Detail
Binding
CHEMBL673750
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In vitro inhibition of endothelin converting enzyme.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.04 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60439 | — | — | 1 | 8.00 |
| CHEMBL301646 | — | — | 1 | 7.75 |
| CHEMBL305089 | — | — | 1 | 7.66 |
| CHEMBL285490 | — | — | 1 | 7.58 |
| CHEMBL61713 | — | — | 1 | 7.55 |
| CHEMBL302837 | — | — | 1 | 7.51 |
| CHEMBL61016 | — | — | 1 | 7.46 |
| CHEMBL304218 | — | — | 1 | 7.33 |
| CHEMBL303302 | — | — | 1 | 7.10 |
| CHEMBL262267 | — | — | 1 | 7.05 |
| CHEMBL293685 | — | — | 1 | 7.05 |
| CHEMBL304629 | — | — | 1 | 7.00 |
| CHEMBL35643 | — | — | 1 | 7.00 |
| CHEMBL304209 | — | — | 1 | 6.96 |
| CHEMBL61640 | — | — | 1 | 6.85 |
| CHEMBL305388 | — | — | 1 | 6.75 |
| CHEMBL59674 | — | — | 1 | 6.68 |
| CHEMBL60363 | — | — | 1 | 6.43 |
| CHEMBL292534 | — | — | 1 | 6.25 |
| CHEMBL59856 | — | — | 1 | 6.12 |
| CHEMBL59762 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60439 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL301646 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL305089 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL285490 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL61713 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL302837 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL61016 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL304218 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL303302 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL262267 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL293685 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL304629 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL35643 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL304209 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL61640 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL305388 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL59674 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL60363 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL292534 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL59856 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL59762 | — | Ki | = | 1460.0 | nM | 5.84 |