Assay Detail

CHEMBL673859

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Binding

Displacement of radioligand from Estrogen receptor alpha

ChEMBL ↗

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Target

Estrogen receptor (CHEMBL206) ↗

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Primary target Estrogen receptor

CHEMBL206

Anchored from Assay target.

Protein identity Estrogen receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Expert

Target

Estrogen receptor (CHEMBL206) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis of a novel fluorescent probe for estrogen receptor.

Adamczyk M, Reddy RE, Yu Z.
Bioorg Med Chem Lett (2002) 12 : 1283 -1285
PubMed 11965371 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	8.68	9.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL411	DIETHYLSTILBESTROL	4.0	1	9.48
CHEMBL135	ESTRADIOL	4.0	1	8.47
CHEMBL83	TAMOXIFEN	4.0	1	8.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL411	DIETHYLSTILBESTROL	IC50	=	0.33	nM	9.48
CHEMBL135	ESTRADIOL	IC50	=	3.4	nM	8.47
CHEMBL83	TAMOXIFEN	IC50	=	8.4	nM	8.08