Assay Detail
Functional
CHEMBL673896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF-stimulated mitogenesis in human umbilical vein endothelial cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor (CHEMBL2095227) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.59 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92516 | — | — | 1 | 6.90 |
| CHEMBL329350 | — | — | 1 | 6.82 |
| CHEMBL92461 | — | — | 1 | 6.41 |
| CHEMBL92279 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92516 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL329350 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL92461 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL92279 | — | IC50 | = | 622.0 | nM | 6.21 |