Compound Detail
CHEMBL92516
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Basic Information
| ChEMBL ID | CHEMBL92516 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VRHNKAXZHXPLGK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
278.3
MW (Da)
3.52
ALogP
5
HBA
0
HBD
43.1
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 6.9 | 6.9 | 127.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 24.0 | nM | 7.62 | Inhibitory activity at VEGF-2 receptor. | 12217372 |
| Vascular endothelial growth factor receptor | IC50 | = | 127.0 | nM | 6.9 | Inhibition of VEGF-stimulated mitogenesis in human umbilical vein endothelial ce... | 12217372 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12217372 | 10.1016/s0960-894x(02)00525-5 | Vascular endothelial growth factor receptor 2 | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta) | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | Vascular endothelial growth factor receptor 2 and 3 (KDR and Flt-4) | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | VEGF-receptor 2 and tyrosine-protein kinase SRC | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | Vascular endothelial growth factor receptor | 1 |
| 12217372 | 10.1016/s0960-894x(02)00525-5 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine